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Film Poster

Witness an extraordinary medical revolution in the battle against cystic fibrosis, the most common fatal genetic disease in the U.S. Once a death sentence, CF saw life expectancies barely reach childhood. But in 2019 an apparent miracle treatment—Trikafta, a potent combination of three drugs—changed everything. People once bedridden and gasping for breath found themselves running marathons. Follow the decades-long scientific quest, fueled by desperate parents, that led to this breakthrough. Experience stories of joy, struggle, and unwavering hope as families confront a disease still marked by profound inequities in diagnosis and treatment. And ponder the implications for the future, as researchers explore whether a new age of “personalized” medicine has finally arrived.

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"This is as clear as science gets."

Fred Van Goor, PhD

"If Kalydeco was a spark, Trikafta was a bonfire."

Kim Cheevers

"What resulted was the concept of venture philanthropy. We were taking philanthropic dollars and becoming venture capitalists."

Bob Beall, PhD, President and CEO Cystic Fibrosis Foundation, 1994-2015

CREDITS

A Wingspan production and HHMI Tangled Bank Studios production in association with NOVA/GBH.

PRODUCED & DIRECTED BY
Catherine Gale
EXECUTIVE PRODUCER FOR WINGSPAN PRODUCTIONS
Archie Baron
EXECUTIVE PRODUCERS FOR HHMI TANGLED BANK STUDIOS
Chad Cohen
Jared Lipworth
EXECUTIVE PRODUCERS FOR NOVA/GBH
Julia Cort
Chris Schmidt